Switching to a different class of antidepressants (e.g. from SSRIs to SNRIs or atypical antidepressants).
Augmenting the current antidepressant with a second medication (e.g. atypical antipsychotics, lithium).
Trying newer antidepressants approved for TRD like esketamine (Spravato) or olanzapine/fluoxetine combination (Symbyax).
Electroconvulsive therapy (ECT) can provide relief for some TRD patients.
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation option.
Deep brain stimulation (DBS) may help interrupt abnormal brain circuits in severe TRD.
Psilocybin, a hallucinogenic compound found in certain mushrooms, is being studied as a potential TRD treatment when combined with psychotherapy.
Cognitive behavioral therapy (CBT) and other talk therapies can be combined with medications.
Mindfulness-based therapies may provide additional benefits.
Regular exercise has been shown to improve mood and reduce depression symptoms.
Stress management techniques like meditation, yoga, and relaxation training.
Improving sleep habits and nutrition.
Psilocybin truffles, which contain psilocybin, are legal in the Netherlands, allowing for the operation of psilocybin retreats. These retreats typically involve consuming psilocybin truffles in a ceremonial setting under the guidance of facilitators. However, psilocybin mushrooms remain illegal.
This legal status has enabled the emergence of psilocybin retreats in the Netherlands, where participants can consume psilocybin truffles in a guided, ceremonial setting under professional supervision.
Organizations like Inwardbound and Synthesis offer legal psilocybin retreats in the Netherlands, catering to individuals seeking personal growth, healing, or exploration of consciousness. These retreats often incorporate preparation and integration programs, psychotherapy, and holistic practices alongside the psilocybin experience. Screening, preparation, and integration programs are included. These typically involve preparation, a psilocybin truffle ceremony, and integration support.
The retreats aim to provide a safe, supportive environment with medical supervision and professional standards. Participants are screened and prepared beforehand, and the psilocybin experience is facilitated by trained practitioners.
Exercise
Healthy Diet
Stress Management
Improving Sleep Habits
Social Support